泽泻对脾虚大鼠骨骼肌线粒体结构的影响(3)
清代醫学家陈修园在《神农本草经读》中提到：“五脏主藏阴，而脾为五脏之原，一得水精之气则能灌溉四旁，俾五脏循环而受益，不特肥健消水不饥，见本藏之功”。因此，笔者推测陈修园所谓泽泻的“养五脏、益气力”功效，其机制可能与泽泻能够改善骨骼肌线粒体能量代谢有关，其具体分子机制还有待于下一步研究。
参考文献
[1]国家药典委员会.中华人民共和国药典[M].北京：中国医药科技出版社，2015：229.
[2] Zhang L L，Xu W，Xu Y L，et al.Therapeutic potential of Rhizoma Alismatis：a review on ethnomedicinal application，phytochemistry，pharmacology，and toxicology[J].Ann N Y Acad Sci，2017，1401(1)：90-101.
, 百拇医药
[3] Shu Z，Pu J，Chen L，et al.Alisma orientale：Ethnopharmacology，Phytochemistry and Pharmacology of an Important Traditional Chinese Medicine[J].Am J Chin Med，2016，44(2)：227-251.
[4] Zhang X，Li X Y，Lin N，et al.Diuretic Activity of Compatible Triterpene Components of Alismatis rhizoma[J].Molecules，2017，22(9)：E1459.
[5] Miao H，Zhang L，Chen D Q，et al.Urinary biomarker and treatment mechanism of Rhizoma Alismatis on hyperlipidemia[J].Biomed Chromatogr，2017，31(4)：e3829.
, 百拇医药
[6] Li S，Jin S，Song C，et al.The metabolic change of serum lysophosphatidylcholines involved in the lipid lowering effect of triterpenes from Alismatis rhizoma on high-fat diet induced hyperlipidemia mice[J].J Ethnopharmacol，2016，177：10-18.
[7] Jeong H S，Cho Y H，Kim K H，et al.Anti-lipoapoptotic effects of Alisma orientalis extract on non-esterified fatty acid-induced HepG2 cells[J].BMC Complement Altern Med，2016，16：239.
[8] Ding C Y，Tan Q Y，Shi N C.Alisma versus Gliclazide in the Treatment of Primary Diabetes in Goto-Kakizaki Rats[J].Zhongguo Yi Xue Ke Xue Yuan Xue Bao，2015，37(4)：451-455.
, 百拇医药
[9] Bi X，Wang P，Ma Q，et al.Anti-Inflammatory Activities and Liver Protection of Alisol F and 25-Anhydroalisol F through the Inhibition of MAPK， STAT3，and NF-kappaB Activation In Vitro and In Vivo[J].Molecules，2017，22(6)：E951.
[10] Kim K H，Song H H，Ahn K S，et al.Ethanol extract of the tuber of Alisma orientale reduces the pathologic features in a chronic obstructive pulmonary disease mouse model[J].J Ethnopharmacol，2016，188：21-30.
, http://www.100md.com [11] Liu J，Zhuang Z J，Tian J，et al.Effect of Compound Zhajin Granule on Toll-like Receptor 4 Signaling Pathway in Nonalcoholic Steatohepatitis Mice[J].Zhongguo Zhong Xi Yi Jie He Za Zhi，2016，36(4)：460-465.
[12] Kim Y，Lee I S，Kim K H，et al.Metabolic Profiling of Liver Tissue in Diabetic Mice Treated with Artemisia Capillaris and Alisma Rhizome Using LC-MS and CE-MS[J].Am J Chin Med，2016，44(8)：1639-1661.
[13] Meng Q，Chen X，Wang C，et al.Protective effects of alisol B 23-acetate from edible botanical Rhizoma alismatis against carbon tetrachloride-induced hepatotoxicity in mice[J].Food Funct，2015，6(4)：1241-1250., 百拇医药(张亚敏 林文津 徐小妹 徐榕青 刘鹏 孙凤灵)
参考文献
[1]国家药典委员会.中华人民共和国药典[M].北京：中国医药科技出版社，2015：229.
[2] Zhang L L，Xu W，Xu Y L，et al.Therapeutic potential of Rhizoma Alismatis：a review on ethnomedicinal application，phytochemistry，pharmacology，and toxicology[J].Ann N Y Acad Sci，2017，1401(1)：90-101.
, 百拇医药
[3] Shu Z，Pu J，Chen L，et al.Alisma orientale：Ethnopharmacology，Phytochemistry and Pharmacology of an Important Traditional Chinese Medicine[J].Am J Chin Med，2016，44(2)：227-251.
[4] Zhang X，Li X Y，Lin N，et al.Diuretic Activity of Compatible Triterpene Components of Alismatis rhizoma[J].Molecules，2017，22(9)：E1459.
[5] Miao H，Zhang L，Chen D Q，et al.Urinary biomarker and treatment mechanism of Rhizoma Alismatis on hyperlipidemia[J].Biomed Chromatogr，2017，31(4)：e3829.
, 百拇医药
[6] Li S，Jin S，Song C，et al.The metabolic change of serum lysophosphatidylcholines involved in the lipid lowering effect of triterpenes from Alismatis rhizoma on high-fat diet induced hyperlipidemia mice[J].J Ethnopharmacol，2016，177：10-18.
[7] Jeong H S，Cho Y H，Kim K H，et al.Anti-lipoapoptotic effects of Alisma orientalis extract on non-esterified fatty acid-induced HepG2 cells[J].BMC Complement Altern Med，2016，16：239.
[8] Ding C Y，Tan Q Y，Shi N C.Alisma versus Gliclazide in the Treatment of Primary Diabetes in Goto-Kakizaki Rats[J].Zhongguo Yi Xue Ke Xue Yuan Xue Bao，2015，37(4)：451-455.
, 百拇医药
[9] Bi X，Wang P，Ma Q，et al.Anti-Inflammatory Activities and Liver Protection of Alisol F and 25-Anhydroalisol F through the Inhibition of MAPK， STAT3，and NF-kappaB Activation In Vitro and In Vivo[J].Molecules，2017，22(6)：E951.
[10] Kim K H，Song H H，Ahn K S，et al.Ethanol extract of the tuber of Alisma orientale reduces the pathologic features in a chronic obstructive pulmonary disease mouse model[J].J Ethnopharmacol，2016，188：21-30.
, http://www.100md.com [11] Liu J，Zhuang Z J，Tian J，et al.Effect of Compound Zhajin Granule on Toll-like Receptor 4 Signaling Pathway in Nonalcoholic Steatohepatitis Mice[J].Zhongguo Zhong Xi Yi Jie He Za Zhi，2016，36(4)：460-465.
[12] Kim Y，Lee I S，Kim K H，et al.Metabolic Profiling of Liver Tissue in Diabetic Mice Treated with Artemisia Capillaris and Alisma Rhizome Using LC-MS and CE-MS[J].Am J Chin Med，2016，44(8)：1639-1661.
[13] Meng Q，Chen X，Wang C，et al.Protective effects of alisol B 23-acetate from edible botanical Rhizoma alismatis against carbon tetrachloride-induced hepatotoxicity in mice[J].Food Funct，2015，6(4)：1241-1250., 百拇医药(张亚敏 林文津 徐小妹 徐榕青 刘鹏 孙凤灵)
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